Specificity and Comments:
BIOCARE’s 100/D5 MAb is highly specific to bcl-2a and shows no cross-reaction with bcl-x or bax protein. Expression of bcl-2? oncoprotein has been shown to inhibit the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2? protein, whereas the normal or hyperplastic germinal centers are negative.
Human; does not react with mouse and rat.
Isotype: IgG1 / ?
A Synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG-Cys), of human bcl-2 protein. 1
Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues)
Positive Control: Follicular lymphomas or tonsil
Cellular Localization: Cell membrane
Buffer with protein carrier and preservative
Storage and Stability:
Store at 4°C. Stable for 18 months.