TIA-1 0,1 mL
Specificity and Comments
TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a
15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes
processing cytolytic potential. The expression of TIA-1 was studied in CD30+
anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell
lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia,
Hodgkin’s etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma
reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large
granular lymphocytic leukemia’s, hepatosplenic T-cell lymphomas, intestinal
T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell
lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T
or NK phenotype. The author’s concluded from TIA-1 studies that anaplastic
large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas,
Hodgkin’s and lymphoblastic leukemia’s were negative for TIA-1.
Species Reactivity: Human; others not tested.
Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded
Anaplastic large cell lymphoma or tonsil
Cellular Localization: Cytoplasmic (granular)
Buffer with carrier protein and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.