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TIA-1 0,1 mL

TIA-1 0,1 mL
Specificity and Comments
TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkin’s etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemia’s, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype. The author’s concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkin’s and lymphoblastic leukemia’s were negative for TIA-1.
Species Reactivity: Human; others not tested.
Clone: TIA-1
Isotype: IgG1
Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues
Positive Control:
Anaplastic large cell lymphoma or tonsil
Cellular Localization: Cytoplasmic (granular)
Supplied As:
Buffer with carrier protein and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.
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