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NKX3.1 (RM) 0,1 ml



Intended Use: IVD

Format: Concentrate, Predilute

By Letter: N

Isotype: IgG

Species Reactivity: Human; others not tested

Source: Rabbit Monoclonal

Clone: EP356

Localization: Nuclear


NKX3.1 is a protein found in humans and is encoded by the NKX3.1 gene located on chromosome 8. The homeodomain containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. NKX3.1 protein has been found to be positive in the vast majority of primary prostatic adenocarcinomas. A recent study showed that NKX3.1 staining was highly sensitive and specific for highgrade prostatic adenocarcinomas. The sensitivity for identifying metastatic prostatic adenocarcinomas overall was 98.6% (68/69 cases positive) for NKX3.1, and 94.2% (65/69 cores positive) for PSA. The specificity of NKX3.1 was 99.7% (1/349) in various cancers. NKX3.1 stains nuclei in both normal and prostate cancer; thus providing a robust stain that is easy-to-interpret, similar to other transcription factors such as TTF-1 or CDX2.

Start > E-line Norge > Immunohistokemi > Antikroppar M-O > NKX3.1 (RM) 0,1 ml