MART-1 cocktail 1,0ml
Specificity and Comments
The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1
(Melanoma Antigen Recognized by T- cells 1) or Melan-A. The MART-1 recognizes a
subcellular fraction found in melanosomes. The antibody labels melanomas and
tumors showing melanocytic differentiation. It does not mark neoplasms of
epithelial origin, lymphomas or mesenchymal tumors. Melan-A is a useful addition
to melanoma panels as it is apparently specific for melanocytic lesions. Both
HMB-45 and MART-1 are coexpressed in the majority of melanomas, as well as
uniquely expressed in certain cases. Studies have shown that MART-1 is more
sensitive than HMB-45 when labeling metastatic melanomas.
Species Reactivity: Human, mouse and rat.
Clone: M2-7C10 + M2-9E3
Isotypes: IgG2b and IgG2b
MART-1 - Recombinant hMart-1 protein
Known Applications: Immunohistochemistry
(formalin-fixed paraffin-embedded tissues)
Positive Control: Melanoma
Cellular Location: Cytoplasmic
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.